Formulation and Evaluation of Fast Disintegrating Orodispersible Tablets of Ondansetron Hydrochloride

The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. The purpose of this research was to mask the intensely bitter taste of Ondansetron HCl and to formulate a orodispersible of the taste-masked drug. Taste masking was done by complexing Ondansetron HCl with Kyron T-134 in different ratios. Drugresin complex were optimized by considering parameters such as optimization of resin concentration, optimization of swelling time, optimization of stirring time, optimization of pH and optimization of temperature on maximum drug loading. The effects of variables were observed in preparation of drug resin complex (resinate), the other variables were kept constant. The resinate was evaluated for taste masking, characterized by and infra red spectrometer. In vitro drug release study of taste masked tablet showed that more than 90 % of the drug release within 20 minutes. Thus, results conclusively demonstrated successful masking of taste and rapid disintegration of the formulated tablets in the oral cavity.